Potassium Citrate

Description

Potassium Citrate is used as a pharmaceutical aid in veterinary practice. It is also used in many pharmacopoeia and other preparations like potassium hydroxide solution, Cresol solution, Soap solution etc. It works as a buffer for juices like real, R-cola etc.

Applications and Effects

Potassium Citrate is mainly used for making solutions in the Pharmaceutical Industry which helps to make parenteral nutrition (the liquid used for making the Injections)

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Specifications

TESTS SPECIFICATIONS

Description

Transparent crystals or white granular powder; odorless saline taste, and is deliquescent when exposed to moist air.

Solubility

Freely soluble in water. Almost insoluble in alcohol.

Identification

(A) A solution (1 in 20) responds to the test for Potassium and for citrate.
Potassium: A White crystalline precipitate that is soluble in 6N ammonium hydroxide.
Citrate: A light red color is produced.

Alkalinity

No pink color is produced by 1 drop of phenolphthalein TS.

Loss on drying

Between 3.0% and 6.0%. Dry it at 180°C for 4 hours.

Tartrate

No precipitate is formed.

Heavy metals

Not more than 0.001%.

Assay

99.0 % to 100.5 % (On dried basis)

TESTS SPECIFICATIONS

Appearance

White or almost white, granular powder or transparent crystals, hygroscopic.

Solubility

Very soluble in water, practically insoluble in ethanol (96%).

Identification
(A) Citrates

A) Violet colour, turning to violet-blue is produced.
B) A white precipitate is produced which is soluble in 6M acetic acid.

(B) Potassium

B) A yellow or orange-yellow precipitate is produced immediately.

Appearance of solution

Solution S is clear and colourless.

Acidity or alkalinity

Not more than 0.2 ml of 0.1M hydrochloric acid or 0.1M
Sodium Hydroxide is required to change the colour of the solution.

Readily carbonisable
Substances

The solution is not more intensely coloured than reference
solution Y2 or GY2

Chloride

Not more than 50 ppm

Oxalate

Not more than 300 ppm (calculated as anhydrous oxalic acid).

Sulphate

Not more than 150 ppm

Heavy metals

Not more than 10 ppm

Sodium

Not more than 0. 3 %

Water

4.0 to 7.0 per cent, determined on 0.250 g.

Assay

99.0 % to 101.0 % (On Anhydrous Basis)

TESTS SPECIFICATIONS

Description

White granular crystals or a white crystalline powder; odourless; hygroscopic.

Solubility

Very soluble in water; soluble in glycerin; practically insoluble
in ethanol (95%).

Identification

(A) Potassium Salts

  1. A yellow or orange-yellow precipitate is produced.
  2. A white crystalline precipitate is produced.
  3. A yellow crystalline precipitate is produced which on

Ignition leaves a residue of kcl and platinum.

(B) Citrates

  1. A white precipitate soluble in 6M acetic acid is produced.
  2. A violet colour which turns violet-blue is produced.

Appearance of solution

Solution A is clear and colourless.

Acidity or alkalinity

Not more than 0.2 ml of 0.1M hydrochloric acid or 0.1M
sodium Hydroxideis required to change the colour of the solution.

Arsenic

Not more than 2 ppm

Heavy metals

Not more than 10 ppm

Sodium

Not more than 0.3 %

Chloride

Not more than 100 ppm

Oxalate

Not more than 300 ppm (calculated as anhydrous oxalic acid).

Sulphate

Not more than 150 ppm

Readily carbonisable
Substances

The solution is not more intensely coloured than reference
solution YS2 or GYS2

Water

4.0 to 7.0 per cent, determined on 0.5 g.

Assay

99.0 % to 101.0 % (On Anhydrous Basis)